Replenix, a distinguished name in medical-grade skincare, was founded in 1981 by Topix Pharmaceuticals, a company established by Stanley and Burt Shaffer with the mission of developing and customizing the highest quality skincare products for dermatologists. Initially, Replenix products were available exclusively through dermatologists, offering physicians potent, medical-grade ingredients and cutting-edge skincare technologies in luxurious, cosmetically elegant formulations designed to maximize visible results with minimal irritation. A hallmark of Replenix's innovation is its proprietary Green Tea Polyphenol Technology. This technology utilizes green tea purified to an unprecedented 90%, making it one of the most potent antioxidant formulations available. These polyphenols are known for their ability to soothe and smooth skin by encouraging the regeneration of healthy skin cells and providing protection against free radicals.
In 2021, responding to growing consumer demand for FDA-approved, medical-grade skincare, Replenix made a pivotal shift by making its products directly available to consumers without the need for a prescription. This transition allowed a broader audience to access the performance-driven products that dermatologists had trusted for decades. Today, Replenix remains committed to its mission of inspiring confidence through healthy skin across generations. The brand continues to revolutionize at-home skincare by incorporating groundbreaking dermatological science and ingredients of unprecedented medical-grade purity, aiming for transformational results. All products are formulated in FDA-approved facilities by leading chemists and dermatologists, ensuring the highest standards of quality, safety, and efficacy.
What sets Replenix skincare apart from other medical-grade skincare brands is its unique combination of cutting-edge dermatological science, clinically proven ingredients, and a heritage rooted in physician-formulated care. One of the brand’s most distinctive innovations is its proprietary Green Tea Polyphenol Technology—an ultra-purified, 90% active green tea extract that delivers powerful antioxidant protection to calm inflammation, neutralize free radicals, and support skin healing. This high concentration is rare and positions Replenix as a leader in antioxidant skincare.
Additionally, Replenix products are known for being exceptionally well-tolerated, even by sensitive skin types, making them a go-to for dermatologists treating rosacea, post-procedure irritation, and compromised skin. Unlike some clinical skincare lines that focus solely on aggressive actives, Replenix balances efficacy with soothing, barrier-supporting ingredients like hyaluronic acid, peptides, ceramides, and niacinamide. Every formula is developed in FDA-regulated facilities and backed by over four decades of clinical research and physician trust. Moreover, Replenix has made its professional-grade formulations accessible to consumers without compromising on quality or safety, delivering dermatologist-trusted results in a user-friendly, elegant experience. This rare combination of performance, purity, and gentle formulation makes Replenix truly stand out in the crowded world of medical-grade skincare.
Replenix Skincare’s best sellers are standout products because they combine clinically backed ingredients with elegant formulations that deliver visible results—making them trusted favorites among dermatologists and consumers alike. Here are a few of their most popular products and why they consistently top the charts:
Replenix Tinted Brightening Eye Cream – This best seller is beloved for its dual-action formula that conceals and treats under-eye concerns. Infused with medical-grade caffeine, peptides, and soothing green tea polyphenols, it visibly reduces puffiness, dark circles, and fine lines. Its sheer, universal tint brightens instantly while treating long-term concerns, making it a morning staple for many.
Replenix Hyaluronic Acid Hydration Serum - An intensely pure, medical-grade, ultra-hydrating serum with fractionated hyaluronic acid that quenches dehydrated, dull skin for a supple, smooth, plump-looking complexion. Visibly reducing the signs of aging, skin appears brighter, firmer, and rejuvenated as skin’s barrier is protected from damaging free radicals. Reduce the signs of aging and protect skin's barrier from free radical damage with REPLENIX Hyaluronic Acid Hydration Serum.
Replenix Retinol + Bakuchiol Concentrate Serum -A clinically proven All-trans-Retinol paired with Bakuchiol, a natural complement to retinol, helps improve the look of discoloration, fine lines, wrinkles, pore size, uneven skin tone and blemishes, with minimal incidence of redness or irritation.
Replenix Soothing Antioxidant Mist – This refreshing facial mist delivers instant hydration and antioxidant protection, thanks to a base of calming green tea, cucumber, chamomile, and caffeine. It's especially popular for on-the-go skin soothing, post-workout refreshment, and post-procedure use.
These best sellers highlight Replenix’s expertise in formulating science-driven, medical-grade skincare that’s gentle enough for daily use, yet powerful enough to produce results. Their blend of high-potency actives with calming botanicals makes them effective, reliable, and consistently recommended by skin professionals.
