Dr. Gail Humble founded Klotho Skin to revolutionize skincare by integrating cutting-edge genetic science with aesthetic medicine. With over two decades of expertise in aesthetic anti-aging, Dr. Humble's passion for regenerative medicine led her to focus on the Klotho gene, a key regulator of aging. She patented a process that genetically modifies human mesenchymal stem cells to upregulate Klotho expression, enabling the reliable production of large quantities of Klotho protein. This innovation allows Klotho Skin products to harness the power of the Klotho protein, aiming to delay aging and promote longevity at the cellular level.
Klotho Skin Cellular Repair Night Crème has been recognized by NewBeauty as one of the best nighttime lifting creams. Featured in their curated list of top products designed to firm and rejuvenate skin overnight, this night cream stands out for its innovative formulation and scientifically backed approach to skincare.
Beyond scientific advancement, Dr. Humble is committed to social responsibility. A portion of Klotho Skin's proceeds supports Women for Women International, aiding marginalized women in conflict zones. Dr. Humble's vision for Klotho Skin is to empower individuals through scientifically-backed skincare solutions that reflect inner beauty and contribute to global well-being.
Klotho Skin distinguishes itself in the skincare industry by integrating cutting-edge regenerative science with advanced growth factor technology. Founded by Dr. Gail Humble, a geneticist and aesthetic anti-aging physician, Klotho Skin is the first skincare line to harness the power of the Klotho protein—an age-suppressing gene known for its role in cellular repair and longevity. The cornerstone of Klotho Skin's efficacy lies in its proprietary Second Generation Growth Factor Technology. Through a patented process, the brand genetically modifies adult mesenchymal stem cells to upregulate the Klotho gene, enhancing the production of growth factors such as Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), and Fibroblast Growth Factor (FGF) These growth factors are then harvested and incorporated into the brand's formulations, comprising 25% of the Cellular Repair Face Serum, 15% of the Eye Serum, and 10% of the Night Creme.
Klotho Skin offers a trio of advanced skincare products-Cellular Repair Face Serum, Cellular Repair Eye Serum, and Cellular Repair Night Creme-each formulated to harness the regenerative power of the Klotho protein and second-generation growth factors. These products are designed to address the multifaceted signs of aging by promoting cellular repair, enhancing collagen production, and improving skin elasticity.
Cellular Repair Face Serum: This serum is the cornerstone of the Klotho Skin line, containing 25% cell-conditioned medium derived from genetically modified mesenchymal stem cells that overexpress the Klotho gene. This formulation delivers a potent blend of growth factors and the Klotho protein, which work synergistically to stimulate collagen synthesis, reduce oxidative stress, and enhance skin hydration, leading to a smoother and more youthful complexion.
- Increase collagen production, smoothing out fine lines
- Increase oxidative stress protection, encouraging even tone and texture
- Decreases Transepidermal Water Loss, increasing skin elasticity

This innovative approach allows Klotho Skin products to penetrate the skin's deeper layers, stimulating collagen production, enhancing elasticity, and promoting overall skin rejuvenation. By addressing the root causes of aging at the cellular level, Klotho Skin offers a scientifically-backed solution for those seeking to restore and maintain youthful skin.
Cellular Repair Eye Serum: Specifically formulated for the delicate eye area, this serum combines 15% cell-conditioned medium with additional ingredients like caffeine and peptides. The Klotho protein's presence helps to reduce puffiness, diminish dark circles, and smooth fine lines by promoting cellular regeneration and protecting against environmental stressors.
- Increse collagen production, smoothing out fine and habitual lines
- Decrease Transepidermal Water Loss, increasing skin firmness
- Increase anti-inflammatory response, promoting healthy skin tone.
Cellular Repair Night Creme: Designed for overnight use, this night cream contains 10% cell-conditioned medium and is enriched with ingredients such as aloe vera and squalane. While the Klotho protein supports the skin's natural repair processes during sleep, the cream's formulation helps to lock in moisture, improve skin elasticity, and reduce transepidermal water loss, resulting in a revitalized and firmer skin appearance by morning.
- Increases collagen production, smoothing out fine lines
- Increase oxidative stress protection, encouraging even tone and texture
- Decreases Transpidermal Water loss, increases skin elasticity
Collectively, these products represent a groundbreaking approach to skincare by integrating genetic science with topical treatments, aiming to not only address visible signs of aging but also to promote long-term skin health and vitality.







